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・ DNA construct
・ DNA damage (naturally occurring)
・ DNA damage checkpoint
・ DNA damage theory of aging
・ DNA damage-binding protein
・ DNA damage-inducible transcript 3
・ DNA Data Bank of Japan
・ DNA database
・ DNA day
・ DNA demethylation
・ DNA digital data storage
・ DNA disruptor
・ DNA extraction
・ DNA field-effect transistor
・ DNA Films
DNA footprinting
・ DNA fragmentation
・ DNA glycosylase
・ DNA gyrase
・ DNA history of Egypt
・ DNA Identification Act (Canada)
・ DNA laddering
・ DNA ligase
・ DNA ligase (NAD+)
・ DNA Lounge
・ DNA machine
・ DNA marking
・ DNA methylation
・ DNA methyltransferase
・ DNA microarray


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DNA footprinting : ウィキペディア英語版
DNA footprinting

DNA footprinting is a method of investigating the sequence specificity of DNA-binding proteins in vitro. This technique can be used to study protein-DNA interactions both outside and within cells.
The regulation of transcription has been studied extensively, and yet there is still much that is not known. Transcription factors and associated proteins that bind promoters, enhancers, or silencers to drive or repress transcription are fundamental to understanding the unique regulation of individual genes within the genome. Techniques like DNA footprinting help elucidate which proteins bind to these associated regions of DNA and unravel the complexities of transcriptional control.
== History ==
In 1978, David Galas and Albert Schmitz developed the DNA footprinting technique to study the binding specificity of the lac repressor protein. It was originally a modification of the Maxam-Gilbert chemical sequencing technique.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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